Category: Study

2017 · Article · Case-Control · CGH · Podcast · Study

GI Pearls Episode 8 – Last two weeks of August 2017 Gastroenterology Literature Review

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Show Notes for last two weeks of August 007

  1. Celiac Disease and Nonceliac Gluten Sensitivity – Jama
  2. Comparison of Infliximab and Adalimumab in Biologic-Naive Patients With Ulcerative Colitis: A Nationwide Danish Cohort Study – Clin Gastro Hep
  3. Use of Thiopurines During Conceptions and Pregnancy is Not Associated with Adverse Pregnancy Outcomes or Health of Infants at One year in a Prospective Study – CGH
  4. Efficacy of Rectal Tacrolimus for Induction Therapy in Patients With Resistant Ulcerative Proctitis – CGH
  5. Use of Liver Imaging and Biopsy in Clinical Practice – NEJM
  6. Hospital-Level Balloon Tamponade Use is Associated with Increased Mortality for All Patients Presenting with Acute Variceal Hemorrhage – Liver international
  7. Clinical Predictors of the Risk of Early Colectomy in Ulcerative Colitis: A Population-based Study – IBD journal
  8. High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic Cohort – CGH
  9. Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study – The Lancet
  10. Efficacy of dietary and physical activity intervention in non-alcoholic fatty liver disease: a systematic review. – BMJ – Gastro
  11. Safety of Adding Oats to a Gluten-Free Diet for Patients With Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies – Gastro
  12. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis – Gastro
  13. Undetectable negative tissue transglutaminase IgA antibodies predict mucosal healing in treated coeliac disease patients – Alimentary Phar and Ther
  14. Death of a Farm Worker After Exposure to Manure Gas in an Open Air Environment – MMWR
2017 · Article · CGH · Podcast · Study

GI Pearls Episode 7 – First two weeks of August 2017 Gastroenterology Literature Review

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Show Notes for 2017 First two weeks of August 007

  1. The colonoscopist’s guide to the vocabulary of colorectal neoplasia: histology, morphology, and management – GIE
  2. Use of enteroscopy for the detection of malignant and premalignant lesions of the small bowel in complicated celiac disease: a meta-analysis – GIE
  3. Impact of cap-assisted colonoscopy on detection of proximal colon adenomas: systematic review and meta-analysis – GIE
  4. Outcomes and quality-of-life assessment after gastric per-oral endoscopic pyloromyotomy – GIE
  5. Randomized controlled trial of scleroligation versus band ligation alone for eradication of gastroesophageal varices – GIE
  6. Endoscopic multiple biopsy and rapid diagnosis by in situ fixation and histopathologic processing – GIE
  7. Diagnostic Accuracy of Fecal Immunochemical Test in Patients at Increased Risk of Colorectal Cancer: A Meta-analysis – Jama:Int Med
  8. Older Adults’ Views and Communication Preferences About Cancer Screening Cessation – Jama Int Med
  9. Celiac Disese and Nonceliac Gluten Sensitivity – A Review – JAMA
  10. Board Review Vignette: PPP Syndrome: Pancreatitis, Panniculitis, Polyarthritis – Am J Gastro
  11. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection – Journal of Hepatology
  12. The impact of a Prior Diagnosis of Barrett’s Esophagus on Esophageal Adenocarcinoma Survival – Am J Gastro
  13. Old Farts – Fact or Fiction? Results From a Population-Based Survey of 16,000 Americans Examining the Association Between Age and Flatus – CGH
2017 · CGH · Podcast · Study

GI Pearls Episode 5 – Last two weeks of June 2017

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Show Notes for 2017 Second two weeks of June 005
  1. Cost Utility Analysis of Topical Steroids Compared With Dietary Elimination for Treatment of Eosinophilic Esophagitis – CGH
  2. Incidence and Prevalence of Crohn’s Disease and Ulcerative Colitis in Olmsted County, Minnesota From 1970 Through 2010 – CGH
  3. Fecal Immunochemical Test Detects Sessile Serrated Adenomas and Polyps With a Low Level of Sensitivity – CGH
  4. Comparison of Two Intensive Bowel Cleansing Regimens in Patients With Previous Poor Bowel Preparation: A Randomized Controlled Study. – GIE
  5. Acute Fatty Liver Disease of Pregnancy: Updates in Pathogenesis, Diagnosis, and Management – ACG
  6. Disentangling the Association between Statins, Cholesterol, and Colorectal Cancer: A Nested Case-Control Study – PLOS Medicine
  7. Association of Gastric Acid Suppression With Recurrent Clostridium difficile InfectionA Systematic Review and Meta-analysis – JAMA Internal Med
  8. Amanita phalloides Mushroom Poisonings — Northern California, December 2016 – MMWR June 2017
  9. Wild Mushrooms: An Exclusive Delicacy or Last Meal – ACG
  10. Treatment of NASH: What Helps Beyond Weight Loss? – ACG
  11. Small intestinal bacterial overgrowth and Celiac disease: A systematic review with pooled-data analysis – Neurogastro & Motility
2015 · Article · Study · Uncategorized

Gastroparesis patient outcomes after 48 weeks

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This Article in December issue of Gastroenterology summarizes the findings from the Gastroparesis Clinical Research Consortium (7 tertiary care centers). Out of 262 patients- only 28% had a reduction in symptoms that was significant.

They also tabulated factors that are associated with reduction in symptoms – male sex, older age, infect196681.jpgious prodrome, antidepressant use, and 4-hr retention greater than 20%.

This is bad news for those with gastroparesis. Most importantly there was no difference in those with and without diabetes.

Most notably there is no post-treatment gastric emptying, which would be interesting to see who actually improved, and who just “felt” better, and whether there is a correlation between these.

 

 

Study

ROLCOL – Right or Left-sided starting position in colonoscopy

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110405-N-KA543-028 SAN DIEGO (April 5, 2011) Hospitalman Urian D. Thompson, left, Lt. Cmdr. Eric A. Lavery and Registered Nurse Steven Cherry review the monitor while Lavery uses a colonoscope on a patient during a colonoscopy at Naval Medical Center San Diego. (U.S. Navy photo by Mass Communication Specialist 2nd Class Chad A. Bascom/Released) I don’t know about you, but during my fellowship thus far, I’ve only done one or two cases where the patient was positioned on the right side. Both were ICU/CCU cases, and both times we’ve reached the cecum without an issue. Positioning in those cases was difficult secondary to all the cardiac/ICU hardware the patient was hooked up to.

This study, which is amazing to see, since it actually examines a commonly held practice, something arose more from tradition/long held beliefs, rather than evidence.  There aren’t that many studies that actually go and do that.

The authors have found that right-sided positioning at the start of the colonoscopy results in a better, quicker, more comfortable procedure. N was about 80 for both arms, and about 75 cases were analyzed in post. Primary outcome was time to reach cecum.

Conclusion – 3 min and 33 seconds (30%) shorter if starter on the right side. Benefit stems largely from improved negotiation of the sigmoid.

Of note, there is a figure in the text, Figure 5, which shows how terrible fellows like me are at doing endoscopy in terms of time to cecal intubation.  Also, shows that the dramatic reduction in time to cecum happens not after 500 colonoscopies, but after 5000 colonoscopies!

We need more of these kinds of studies. The types that test “tried and true” practices, simple design, simple conclusions.