Podcast

GI Pearls – August 2018 – Episode 23

Show Notes for August 2018 – Episode 23
  1. Crohn’s giudelines – Am J Gastro

Yes there are no podcasts between May 2018 and August 2018.

Please e-mail me at info at gipearls.com if you have suggestions for papers to discuss, or comments/concerns.

Podcast

GI Pearls – May 2018 – Episode 22

Show Notes for May 2018 – Episode 22  – Peptic ulcers, Infections in IBD, EOE, dyspepsia, Infliximab, Pancreatic cysts. etc. Email me – info@gipearls.com if you want to meet up at DDW
Podcast

GI Pearls – April 2018 – Episode 21

Show Notes for April 2018 – Episode 21

Don’t forget to send your e-mail to info@gipearls.com  for the mailing list.

Podcast

GI Pearls – March 2018 – Episode 19

Show Notes for March 2018 – Episode 18

On this epsiode I interview Jay Luther, MD from Massachusetts General Hospital on his Editorial on liver transplantation for alcoholic hepatitis.

Other papers:

 

2018 · Podcast

GI Pearls – February 2018 – Episode 17

Show Notes for February 2018 – Episode 17
  1. Cap cuff-assisted colonoscopy versus standard colonoscopy for adenoma detection: a randomized back-to-back study – GIE
  2. Risk of Clostridium difficile infection in Patients with Celiac Disease – Am J Gastro
  3. Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome – Lancet Gastro
  4. “Weekend Effect” in patients with UGI Hemorrahge: Systematic Review – Am J Gastro
  5. Sleeve Gastrrectomy vs Rough-en-Y – JAMA
  6. Bariatric surgery vs obesity with long-term medical complications and obesity related comorbidites. – JAMA
  7. Reassessing the Safety Concerns of Utilizing Blood Donations from Patients with Hemochromatosis – Hepatology
  8. PPIs associated with increased mortality in patients with pyogenic liver abscess – AP&T
  9. Optimal Histologic Cutpoints for Tretment response in Patients with Eosinophilic Esophagitis – CGH
  10. Pedunculated Laryngeal Hemangioma in a Patient With Suspected Atypical Symptoms of GERD – CGH
  11. AGA – Acute Pancreatitis Guidelines – Gastro
2017

GI Pearls – October 1-15 2017 – Episode 11

Show Notes for October 1-15, 2017  Episode 011
  1. Postcolonoscopy mortality: Bowel preparation to blame? – GIE
  2. Prevalence of hypokalemia before and after bowel preparation for colonoscopy in high-risk patients – GIE
  3. Prevalence of Anemia 10 Years After Roux-en-Y Gastric Bypass in a Single Veterans Affairs Medical Center – Jama Surgery
  4. Risk of Postop Complications Among IBD paietns treated Preop with Vedolizumab – Am J Gastro
  5. Physician Characteristics Associated with Higher Adenoma Detection Rate – GIE
  6. Electrolyte Disturbances in Patients with Chronic Alcohol-Use Disorders  – NEJM
  7. Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management. – Am J Gastro
  8. Calcium Oxalate Crystals in Ethylene Glycol Toxicity – NEJM
  9. Celiac Disease and Autoimmunity — The Missing Ingredient– NEJM
  10. Statin Use and Risk of Cirrhosis and Related Complications in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis – CGH
  11. The risk of hepatocellular carcinoma is decreasing after the first 5 years of tx – Hepatology
  12. Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia – Science -TM
  13.  Hepatitis C Virus Screening in New York – MMWR
  14. Outbreak of Campylobacter jejuni – MMWR
2017 · Podcast

GI Pearls – September 1-15 2017 – Episode 9

Show Notes for September 1-15 2017  Episode 009
  1. Asthma Is Associated With Subsequent Development of Inflammatory Bowel Disease: A Population-based Case–Control Study  – CGH
  2. Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial – Blood
  3. Therapeutic endoscopy-related GI bleeding and thromboembolic events in patients using warfarin or direct oral anticoagulants: results from a large nationwide database analysis – Gut
  4. Major Bleeding Risk During Anticoagulation with Warfarin, Dabigatran, Apixaban, or Rivaroxaban in Patients with Nonvalvular Atrial Fibrillation. – J of Managed Care & Spec Pharm
  5. Oral administration of conditioned medium obtained from mesenchymal stem cell culture prevents subsequent stricture formation after esophageal submucosal dissection in pigs. – GIE
  6. High Dietary Intake of Specific Fatty Acids Increases Risk of Flares in Patients With Ulcerative Colitis in Remission During Treatment With Aminosalicylates – CGH
  7. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Inherited Polyposis Syndromes – Dis of Col and Rectum.
  8. Measurement Bias of Polyp Size at Colonoscopy – Dis of Col and Rectum.
  9. Chronic Pancreatitis and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis – Am J Gastro.
  10. Rural and Urban Residence During Early Life is Associated with Risk of Inflammatory Bowel Disease – AmJGastro
  11. What’s new in Rome IV – Neurogastro & Motility
  12. Fecal Calprotectin Levels Predict Histological Healing in Ulcerative Colitis – IBD Journal
  13. Weight and Metabolic Outcomes 12 Years after Gastric Bypass – NEJM
Podcast · Uncategorized

GI Pearls Episode 6 – First two weeks of July 2017 Gastroenterology Literature Review

Show Notes for 2017 First two weeks of July 006
  1. Treatment with Biologic Agents has not Reduced Surgeries among Patients with Crohn’s Disease with Short Bowel Syndrome – CGH
  2. Risk of colorectal cancer in chronic liver diseases: a systematic review and meta-analysis – GIE
  3. Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection among Metabolically Healthy Obese Adults – JAMA Internal Medicine
  4. Urgent colonoscopy in patients with lower GI bleeding: a systematic review and meta-analysis – GIE
  5. Mobile phone in the stomach:call the emergency endoscopist! – GIE
  6. Impact of gum chewing on the quality of bowel preparation for colonoscopy: an endoscopist-blinded, randomized controlled trial – GIE
  7. Hepatitis B reactivation in Hepatitis B and C coinfected Patients treated with Antiviral Agents: A systematic Review and Meta-analysis. – Hepatology
  8. Gastostomies Preserve But Do Not Increease Quality of Life for Patients and Caregivers – CGH
  9. “Errare Humanum Est, Perseverare Autem Diabolicum” – Gastro
  10. Association of Changes in Diet Quality with Total and Cause-Specific Mortality – NEJM
  11. Association Between Proton Pump Inhibitor Use and Cognitive Function in Women – Gastro
  12. Increased Rate of Adenoma Detection Associates with Reduced Risk of Colorectal Cancer and Death – Gastro
  13. Risk Factors for 30-day Hospital Readmission for Diverticular Hemorrhage. – J of Clinical Gastro
2015 · Article · Case-Control

Unexpected reduction in polyp numbers in Chronic Inflammatory conditions of the Colon

Tubular_adenoma_4_low_magI have read this article back in July, and immediately found it interesting.  One reason is that it is (albeit a poor one) an example of the use of “Big Data” type analysis where a large database of patient biopsy specimens can be searched.

Second reason – is the actual clinical finding – less polyps than expected in those with microscopic colitis – prevalence of ALL types of polyps was reduced.

Summary:  130,000 patients with symptoms of diarrhea had a colonoscopy with biopsies.  Compared with 97,000 control cases.  So, in this CASE-CONTROL study for patients with workup of diarrhea – less polyps (Odds ratios = 0.46 for hyperplastic, 0.24for serrated adenomas, and 0.35 for tubular adenomas).

Criticism: It would have been nice if the authors have age-matched the cases one for one from the beginning, even though these were adjusted for. There is no duration of disease, so the mechanism would remain elusive. Although it would be interesting to have someone do a database review of patients whose clinical history is known. It can even be compared to the current study, if the data is available, i.e. authors had 14% of colons have polyps in normals, and 8.3% in microscopic colitis,  is there an influence of disease duration or is this an all or none phenomenon?