- Asthma Is Associated With Subsequent Development of Inflammatory Bowel Disease: A Population-based Case–Control Study – CGH
- Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial – Blood
- Therapeutic endoscopy-related GI bleeding and thromboembolic events in patients using warfarin or direct oral anticoagulants: results from a large nationwide database analysis – Gut
- Major Bleeding Risk During Anticoagulation with Warfarin, Dabigatran, Apixaban, or Rivaroxaban in Patients with Nonvalvular Atrial Fibrillation. – J of Managed Care & Spec Pharm
- Oral administration of conditioned medium obtained from mesenchymal stem cell culture prevents subsequent stricture formation after esophageal submucosal dissection in pigs. – GIE
- High Dietary Intake of Specific Fatty Acids Increases Risk of Flares in Patients With Ulcerative Colitis in Remission During Treatment With Aminosalicylates – CGH
- The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Inherited Polyposis Syndromes – Dis of Col and Rectum.
- Measurement Bias of Polyp Size at Colonoscopy – Dis of Col and Rectum.
- Chronic Pancreatitis and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis – Am J Gastro.
- Rural and Urban Residence During Early Life is Associated with Risk of Inflammatory Bowel Disease – AmJGastro
- What’s new in Rome IV – Neurogastro & Motility
- Fecal Calprotectin Levels Predict Histological Healing in Ulcerative Colitis – IBD Journal
- Weight and Metabolic Outcomes 12 Years after Gastric Bypass – NEJM
- Treatment with Biologic Agents has not Reduced Surgeries among Patients with Crohn’s Disease with Short Bowel Syndrome – CGH
- Risk of colorectal cancer in chronic liver diseases: a systematic review and meta-analysis – GIE
- Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection among Metabolically Healthy Obese Adults – JAMA Internal Medicine
- Urgent colonoscopy in patients with lower GI bleeding: a systematic review and meta-analysis – GIE
- Mobile phone in the stomach:call the emergency endoscopist! – GIE
- Impact of gum chewing on the quality of bowel preparation for colonoscopy: an endoscopist-blinded, randomized controlled trial – GIE
- Hepatitis B reactivation in Hepatitis B and C coinfected Patients treated with Antiviral Agents: A systematic Review and Meta-analysis. – Hepatology
- Gastostomies Preserve But Do Not Increease Quality of Life for Patients and Caregivers – CGH
- “Errare Humanum Est, Perseverare Autem Diabolicum” – Gastro
- Association of Changes in Diet Quality with Total and Cause-Specific Mortality – NEJM
- Association Between Proton Pump Inhibitor Use and Cognitive Function in Women – Gastro
- Increased Rate of Adenoma Detection Associates with Reduced Risk of Colorectal Cancer and Death – Gastro
- Risk Factors for 30-day Hospital Readmission for Diverticular Hemorrhage. – J of Clinical Gastro
I have read this article back in July, and immediately found it interesting. One reason is that it is (albeit a poor one) an example of the use of “Big Data” type analysis where a large database of patient biopsy specimens can be searched.
Second reason – is the actual clinical finding – less polyps than expected in those with microscopic colitis – prevalence of ALL types of polyps was reduced.
Summary: 130,000 patients with symptoms of diarrhea had a colonoscopy with biopsies. Compared with 97,000 control cases. So, in this CASE-CONTROL study for patients with workup of diarrhea – less polyps (Odds ratios = 0.46 for hyperplastic, 0.24for serrated adenomas, and 0.35 for tubular adenomas).
Criticism: It would have been nice if the authors have age-matched the cases one for one from the beginning, even though these were adjusted for. There is no duration of disease, so the mechanism would remain elusive. Although it would be interesting to have someone do a database review of patients whose clinical history is known. It can even be compared to the current study, if the data is available, i.e. authors had 14% of colons have polyps in normals, and 8.3% in microscopic colitis, is there an influence of disease duration or is this an all or none phenomenon?