Podcast

GI Pearls – November-December 2017 – Episode 13

Show Notes for November-December 2017 – Episode 13
  1. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study – GUT
  2. Association Between Use of Thiopurines or Tumor Necrosis Factor Antagonists Alone or in Combination and Risk of Lymphoma in Patients With IBD – JAMA
  3. Complications of Bariatric Surgery: What You Can Expect to See in Your GI Practice – Am Journal Gastro
  4. Oversuse of Repeat Upper Endoscopy in the Veterans Health Administration: A Retrospective Analysis – Am Journal Gastro
  5. Estrogen replacement reduces risk and increases survival time in of women with HCC – CGH
  6. Hepatitis C virus testing for case identification in persons born during 1945–1965: Results from three randomized controlled trials. –  Hepatology
  7. Population based paternity rate and partner birth outcomes among Utah men with IBD – Am J Gastro
  8. Agreement between home-based Measurement of stool calprotectin and ELISA Results for Monitoring Inflammatory Bowel Disease Activity – CGH
  9. Prevalence of Eosinophilic Gastroenteritis and Colitis in a Population-based Study – CGH
  10. Tongxie Formula Reduces Symptoms of Irritable Bowel Syndrome – CGH
  11. Chromoendoscopy for Surveillance in Ulcerative Colitis and Crohn’s Disease: A Systematic Review of Randomized Trials – CGH
  12. Long-Term Efficacy and Safety of Cyclosporine in a Cohort of Steroid-Refractory Acute Severe Ulcerative Colitis Patients from the ENEIDA Registry (1989–2013): A Nationwide Multicenter Study – Am J Gastro
2017

GI Pearls – October 1-15 2017 – Episode 11

Show Notes for October 1-15, 2017  Episode 011
  1. Postcolonoscopy mortality: Bowel preparation to blame? – GIE
  2. Prevalence of hypokalemia before and after bowel preparation for colonoscopy in high-risk patients – GIE
  3. Prevalence of Anemia 10 Years After Roux-en-Y Gastric Bypass in a Single Veterans Affairs Medical Center – Jama Surgery
  4. Risk of Postop Complications Among IBD paietns treated Preop with Vedolizumab – Am J Gastro
  5. Physician Characteristics Associated with Higher Adenoma Detection Rate – GIE
  6. Electrolyte Disturbances in Patients with Chronic Alcohol-Use Disorders  – NEJM
  7. Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management. – Am J Gastro
  8. Calcium Oxalate Crystals in Ethylene Glycol Toxicity – NEJM
  9. Celiac Disease and Autoimmunity — The Missing Ingredient– NEJM
  10. Statin Use and Risk of Cirrhosis and Related Complications in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis – CGH
  11. The risk of hepatocellular carcinoma is decreasing after the first 5 years of tx – Hepatology
  12. Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia – Science -TM
  13.  Hepatitis C Virus Screening in New York – MMWR
  14. Outbreak of Campylobacter jejuni – MMWR
Podcast · Uncategorized

GI Pearls Episode 6 – First two weeks of July 2017 Gastroenterology Literature Review

Show Notes for 2017 First two weeks of July 006
  1. Treatment with Biologic Agents has not Reduced Surgeries among Patients with Crohn’s Disease with Short Bowel Syndrome – CGH
  2. Risk of colorectal cancer in chronic liver diseases: a systematic review and meta-analysis – GIE
  3. Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection among Metabolically Healthy Obese Adults – JAMA Internal Medicine
  4. Urgent colonoscopy in patients with lower GI bleeding: a systematic review and meta-analysis – GIE
  5. Mobile phone in the stomach:call the emergency endoscopist! – GIE
  6. Impact of gum chewing on the quality of bowel preparation for colonoscopy: an endoscopist-blinded, randomized controlled trial – GIE
  7. Hepatitis B reactivation in Hepatitis B and C coinfected Patients treated with Antiviral Agents: A systematic Review and Meta-analysis. – Hepatology
  8. Gastostomies Preserve But Do Not Increease Quality of Life for Patients and Caregivers – CGH
  9. “Errare Humanum Est, Perseverare Autem Diabolicum” – Gastro
  10. Association of Changes in Diet Quality with Total and Cause-Specific Mortality – NEJM
  11. Association Between Proton Pump Inhibitor Use and Cognitive Function in Women – Gastro
  12. Increased Rate of Adenoma Detection Associates with Reduced Risk of Colorectal Cancer and Death – Gastro
  13. Risk Factors for 30-day Hospital Readmission for Diverticular Hemorrhage. – J of Clinical Gastro
2017 · CGH · Podcast

GI Pearls Episode 2 – First two weeks of May 2017

Show Notes for 2017 May 1- 15 002

 This one is a bit noisy. Not the Best Microphone. Sorry. 

List of articles cited

  1. Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis NEJM
  2. Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis  – Jama Internal Medicine
  3. Tenapanor Treatment of Patients With Constipation-Predominant Irritable Bowel Syndrome: A Phase 2, Randomized, Placebo-Controlled Efficacy and Safety Trial  The AmJ of Gastro
2015 · Article · Uncategorized

AJM300 – Oral Therapy for Ulcerative Colitis

I am surprised that there are so few new oral drugs coming out for IBD. I guess Infusions are all the rage due to potential profits.  AJM300 has been around for a while, and I remember seeing an abstract for it at DDW last year.

This Article – in Gastroenterology, which has been online for a while, finally came out in print edition.

AJM300 is an alpha4 integrin antagonist. In their paper describing a double-blind, placebo-controlled phase 2a study, AJM300 was shown to be well tolerated and more effective than placebo including both clinical response, remission and mucosal healing.

For those of you like me, who do not remember what Phase 2a is – Pilot clinical trials to evaluate efficacy ( and safety) in selected populations of patients with the disease or condition to be treated, diagnosed, or prevented. Objectives may focus on dose-response, type of patient, frequency of dosing, or numerous other characteristics of safety and efficacy.  (2B being a larger study showing efficacy, the so-called “Pivotal trial”).

Another interesting statement in the article made me aware of the number of cases of PML as a result of Natalizumab treatment – 2.1 cases per 1000 (total of 212 cases out of 99,751 patients treated). Two take aways for me – I had no idea that many patients were treated with Ntalizumab!!!I had no idea that there was a registry, but that makes sense.

Once again, remember,  JCV negative patients never get PML.

Lastly, efficacy in this group: I will only mention mucosal healing which is most important for these pilot studies:  58.8% – AJM300 versus 29.4% in placebo group. – another reminder that a third of patients with UC will just get better.